Search Results for: placenta

Epigenetic similarities between placental and cancer cells

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This 2017 New Zealand review compared and contrasted epigenetic evidence from placental and cancer research: “Placental and cancer cells are globally hypomethylated and share an epigenetic phenomenon that is not well understood – they fail to silence repetitive DNA sequences (retrotransposons) that are silenced (methylated) in healthy somatic cells. In the placenta, hypomethylation of retrotransposons … Continue reading Epigenetic similarities between placental and cancer cells

Eat broccoli sprouts for depression, Part 2

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Here are three papers that cited last year’s Part 1. First is a 2021 rodent study investigating a microRNA’s pro-depressive effects: “Depressive rat models were established via chronic unpredicted mild stress (CUMS) treatment. Cognitive function of rats was assessed by a series of behavioral tests. Nrf2 was weakly expressed in CUMS-treated rats, whereas Nrf2 upregulation … Continue reading Eat broccoli sprouts for depression, Part 2

Sulforaphane vs. too much oxygen

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This 2021 rodent study investigated perinatal effects of hyperoxia and sulforaphane: “We demonstrated that early-life oxidant-induced acute lung injury had significant consequences later in life on NRF2-dependent respiratory syncytial virus (RSV) susceptibility in mice. We also determined that increased antioxidant conditions in utero potentially contribute to a decreased risk of postnatal airway disease as we … Continue reading Sulforaphane vs. too much oxygen

A broccoli sprouts study that lacked evidence for human applicability

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A 2020 study Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor–Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice (not freely available) conclusion was: “Lifelong BSp [broccoli sprouts] and GTP [green tea polyphenol] administration can prevent estrogen receptor–negative mammary tumorigenesis through cell cycle arrest and … Continue reading A broccoli sprouts study that lacked evidence for human applicability

Nano-sulforaphane vs. barbecue chemicals

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This 2020 chicken study investigated the capability of nano-sulforaphane to protect embryonic survival and neurogenesis from a barbecued meat chemical: “Common teratogenic [of, relating to, or causing malformations of an embryo or a fetus] factors related to the development of the nervous system, such as alcohol consumption and smoking, have attracted wide attention. Teratogenic factors … Continue reading Nano-sulforaphane vs. barbecue chemicals

Take responsibility for your one precious life – Vitamin D3

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Where to start among 6,489 studies and reviews published during the past five years, results from a PubMed search of “dihydroxyvitamin D3.” How about: “Vitamin D plays a fundamental role in body calcium and phosphorous homeostasis, ensuring proper functioning of the skeletomuscular system. Pleiotropic activities include: Anti-inflammatory and immunomodulatory properties (predominantly downregulation of adaptive and … Continue reading Take responsibility for your one precious life – Vitamin D3

The epigenetics of perinatal stress

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This 2019 McGill review discussed long-lasting effects of perinatal stress: “Epigenetic processes are involved in embedding the impact of early-life experience in the genome and mediating between social environments and later behavioral phenotypes. Since these phenotypes are apparent a long time after early experience, changes in gene expression programming must be stable. Although loss of … Continue reading The epigenetics of perinatal stress

Clearing out the 2019 queue of interesting papers

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I’m clearing out the below queue of 27 studies and reviews I’ve partially read this year but haven’t taken the time to curate. I have a pesky full-time job that demands my presence elsewhere during the day. :-\ Should I add any of these back in? Let’s be ready for the next decade! Early life … Continue reading Clearing out the 2019 queue of interesting papers

A review of fetal adverse events

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This 2019 Australian review subject was fetal adversities: “Adversity during the perinatal period is a significant risk factor for the development of neurodevelopmental disorders long after the causative event. Despite stemming from a variety of causes, perinatal compromise appears to have similar effects on the developing brain, thereby resulting in behavioural disorders of a similar … Continue reading A review of fetal adverse events

PNAS politics in the name of science

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This 2019 Germany/Canada human fetal cell study was a Proceedings of the National Academy of Sciences of the United States of America direct submission: “In a human hippocampal progenitor cell line, we assessed the short- and long-term effects of GC [glucocorticoid] exposure during neurogenesis on messenger RNA expression and DNA methylation profiles. Our data suggest … Continue reading PNAS politics in the name of science

Effects of advanced glycation end products on quality of life and lifespan

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This 2018 Chinese review concerned advanced glycation end products (AGE) mobility interventions: “Only a limited number of studies have focused on measuring the effects of low AGEs levels or AGEs inhibitors on mobility, although many observational human studies and in vitro studies have reported the correlation of AGEs with and the contribution of AGEs to … Continue reading Effects of advanced glycation end products on quality of life and lifespan

Prenatal programming of human HPA axis development

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This 2017 UC Irvine human review subject provided details of how fetal hypothalamic-pituitary-adrenal components and systems develop, and how they are epigenetically changed by the mother’s environment: “The developmental origins of disease or fetal programming model predicts that intrauterine exposures have life-long consequences for physical and psychological health. Prenatal programming of the fetal hypothalamic-pituitary-adrenal (HPA) … Continue reading Prenatal programming of human HPA axis development

The lack of oxygen’s epigenetic effects on a fetus

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This 2018 Loma Linda review subject was gestational hypoxia: “Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis … Continue reading The lack of oxygen’s epigenetic effects on a fetus

in utero prevention of breast cancer by a broccoli sprouts diet

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This 2018 Alabama rodent study investigated the epigenetic effects on developing breast cancer of timing a sulforaphane-based broccoli sprouts diet. Timing of the diet was as follows: Conception through weaning (postnatal day 28), named the Prenatal/maternal BSp (broccoli sprouts) treatment (what the mothers ate starting when they were adults at 12 weeks until their pups … Continue reading in utero prevention of breast cancer by a broccoli sprouts diet

Immune memory of pregnancies

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This 2018 Israeli human study subject was natural killer cell epigenetic memory of pregnancies: “Natural killer (NK) cells were first discovered for their ability to kill tumor cells, and later found to also kill pathogen-infected cells. Different tissue-resident subpopulations of human NK cells exist throughout the body, displaying unique phenotypic and functional properties. One of … Continue reading Immune memory of pregnancies