Changing an inflammatory phenotype with broccoli sprouts

This follow up to Growing a broccoli sprouts Victory Garden is what’s gone on during Week 1 of starting to grow broccoli sprouts for a “30 grams of fresh broccoli sprouts incorporated daily into the diet” [1] program. Day 0 – I’ve tried many things to cure chronic inflammation over the years, basing most of … Continue reading Changing an inflammatory phenotype with broccoli sprouts

Humans individually evolve by..?

This 2020 UK evolutionary biology article was part of a “Fifty years of the Price equation” issue: “Genetic and non-genetic inheritance usually produce a phenotype [the composite of an organism’s characteristics, including its developmental, biophysical, and behavioral traits] through a highly complex developmental process that also relies on many features of the world over which … Continue reading Humans individually evolve by..?

The epigenetics of perinatal stress

This 2019 McGill review discussed long-lasting effects of perinatal stress: “Epigenetic processes are involved in embedding the impact of early-life experience in the genome and mediating between social environments and later behavioral phenotypes. Since these phenotypes are apparent a long time after the early experience, the changes in gene expression programming must be stable. Although … Continue reading The epigenetics of perinatal stress

Epigenetic inheritance and microRNAs

This 2019 Canadian rodent study found: “Folic acid (FA) supplementation mitigates sperm miRNA profiles transgenerationally following in utero paternal exposure to POPs [persistent organic pollutants]. Across the F1 – F4 generations, sperm miRNA profiles were less perturbed with POPs + FA compared to sperm from descendants of dams treated with POPs alone..and only in F1 … Continue reading Epigenetic inheritance and microRNAs

An epigenetic clock review by committee

This 2019 worldwide review of epigenetic clocks was a semi-anonymous mishmash of opinions, facts, hypotheses, unwarranted extrapolations, and beliefs. The diversity of viewpoints among the 21 coauthors wasn’t evident. 1. Citations of the coauthors’ works seemed excessive, and they apologized for omissions. However: Challenge 5 was titled “Single-cell analysis of aging changes and disease” and … Continue reading An epigenetic clock review by committee

A transgenerational view of the rise in obesity

This 2019 Washington State University rodent study found epigenetically inherited transgenerational effects in great-grand offspring due to their great-grandmothers’ toxicant exposures during pregnancy: “Previous studies found an increased susceptibility to obesity in F3 generation rats ancestrally exposed to the pesticide DDT, and an increase in a lean phenotype in the F3 generation rats ancestrally exposed … Continue reading A transgenerational view of the rise in obesity

A GWAS meta-analysis of two epigenetic clocks

This 2019 UK human study conducted a meta-analysis of genome-wide association studies of two epigenetic clocks using 13,493 European-ancestry individuals aged between ten and 98 years: “Horvath-EAA, described in previous publications as ‘intrinsic’ epigenetic age acceleration (IEAA), can be interpreted as a measure of cell-intrinsic ageing that exhibits preservation across multiple tissues, appears unrelated to … Continue reading A GWAS meta-analysis of two epigenetic clocks

Organismal aging and cellular senescence

I’ll curate this 2019 German review through its figures: “With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Figure 1. Current determinants and relevant open questions, marking the processes of aging and … Continue reading Organismal aging and cellular senescence

Emotional responses and BDNF methylation

This 2019 German human study found: “A critical role of BDNF [brain-derived neurotrophic factor] methylation in human amygdala response to negative emotional stimuli, whereby: High BDNF methylation rates were for the first time shown to be associated with a high reactivity in the amygdala; and High BDNF methylation and high amygdala reactivity were associated with … Continue reading Emotional responses and BDNF methylation

Reversing epigenetic T cell exhaustion

This 2019 worldwide discussion among 18 experts concerned T cell exhaustion: “‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Key questions remain about the potential to … Continue reading Reversing epigenetic T cell exhaustion