While getting ready for bed tonight, I mused about how my younger brother had such an idealized postmortem view of our father. As he expressed six years ago in an obituary for our high school Literature teacher: “I’ll remember my favorite teacher and how much he’s meant to my life. My father and Martin Obrentz … Continue reading We believe what we need to believe
Yesterday’s team meeting at work provided one display after another of a person’s need to feel important. These eye-openers were the reason the scheduled 30-minute meeting lasted 45 minutes. Although half of the forty or so attendees are under the age of 40, curiously, only two of them spoke during the meeting. I wasn’t among … Continue reading Your need to feel important will run your life, and you’ll never feel satisfied
A coauthor of the studies referenced in: Advance science by including emotion in research; and Empathy, value, pain, control: Psychological functions of the human striatum offered an opinion piece in A Paper a Day Keeps the Scientist Okay entitled “Do We Need To Study The Brain To Understand The Mind?” “The emerging consensus appears to … Continue reading Do we need to study the brain to understand the mind?
A magazine article New Clues to How the Brain Maps Time reviewed the findings of a 2015 Boston rodent study During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run. The article’s information was mixed such that when the reader arrived at this phrase: “Moreover, time cells rely on context; they only mark … Continue reading Publicly-funded researchers need to provide unqualified free access to their studies
This 2014 wild chimpanzee study demonstrated how necessary it was to have a mother’s “nourishment, transportation, warmth, protection, and socialization,” in other words, a mother’s love, during infancy and early childhood. http://www.pnas.org/content/111/51/18189.full “Early social exposure in wild chimpanzees: Mothers with sons are more gregarious than mothers with daughters”
Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals
After reading through findings of several dozen rodent studies this evening, I thought it would be worthwhile to revisit analysis of human relevance provided by one paper of How much sulforaphane is suitable for healthy people? “Comparisons of published oral doses of sulforaphane administered to mice or rats and sulforaphane (tablets or sulforaphane-rich broccoli preparations) … Continue reading Human relevance of rodent sulforaphane studies
This 2020 meta-analysis subject was DHEA: “Twenty-four qualified trials were included in this meta-analysis. Statistically significant increases in serum IGF-1 levels were found only in participants who were: Women; or Supplementing 50 mg/d; or Undergoing intervention for > 12 weeks; or Without an underlying comorbidity; or Over the age of 60 years. DHEA supplementation led … Continue reading Take responsibility for your one precious life – DHEA
This 2018 review explained: “Aging is the sum of all age-related diseases. Aging and its diseases are inseparable, as these diseases are manifestations of aging. An aged appearance (e.g., grey hair, wrinkles, cushingoid body types and loss of muscles) are manifestations of pre-diseases. For example, an aged appearance may reflect hypercortisolism, sarcopenia, osteoporosis, skin pre-diseases. … Continue reading Aging as a normal disease
This 2020 Swiss review subject was the interaction of Nrf2 activators and skin: “The electrophile and Nrf2 activator dimethyl fumarate (DMF) is an established and efficient drug for patients suffering from the common inflammatory skin disease psoriasis. DMF is being tested for pharmacological activity in several other inflammatory skin conditions. Psoriasis is a chronic inflammatory … Continue reading Eat broccoli sprouts for your skin!
This 2020 Texas review subject was long non-coding RNAs: “We review the emerging significance of long non-coding RNAs (lncRNA) as downstream targets and upstream regulators of the Nrf2 signaling pathway, a critical mediator of diverse cellular processes linked to increased cell survival. It is believed that more than 3% of human genes are regulated by … Continue reading Sulforaphane and RNAs
This 2020 French human cell study found: “Exposure of mononuclear phagocytes to β-glucan contributes to the induction of innate immune memory, which is associated with long-term epigenetic, metabolic, and functional reprogramming. We investigated how preincubation of human monocytes with particulate β-glucan affects the biological response of macrophages following NLRP3 inflammasome activation. Upon infection or cellular … Continue reading Reprogram inflammation with β-glucan
To follow up Caution on broccoli seed erucic acid content? this 2020 German review sympathetically analyzed government overreach on erucic acid contents in several foods: “We measured exemplarily samples of rapeseed, mustard, further Brassicaceae and used the data to discuss possible consequences for consumers, producers and the food sector. This data was supplemented with possible … Continue reading Politically correct about erucic acid and broccoli seeds
This 2019 Spanish human study ran in parallel with Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts. I’ll focus on the aspect of diindolylmethane (DIM) from eating broccoli sprouts: “The aim of this study is to evaluate the effect of gender or hormonal status (menopause) on the bioavailability of broccoli … Continue reading Eat broccoli sprouts for DIM
Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts