This 2018 UK paper reviewed genomic imprinting: “Since their discovery nearly 30 years ago, imprinted genes have been a paradigm for exploring the epigenetic control of gene expression. Moreover, their roles in early life growth and placentation are undisputed. However, it is becoming increasingly clear that imprinted gene function has a wider role in maternal … Continue reading Genomic imprinting and growth
This 2016 Italian review subject was the interplay of genetic imprinting and sleep regulation: “Sleep results from the synergism between at least two major processes: a homeostatic regulatory mechanism that depends on the accumulation of the sleep drive during wakefulness, and a circadian self-sustained mechanism that sets the time for sleeping and waking throughout the … Continue reading Genetic imprinting, sleep, and parent-offspring conflict
This 2016 UK human study assessed the roles of genetic imprinting on diseases that may originate from a certain interval on chromosome 15: “The 15q11.2-q13.3 region contains a cluster of imprinted genes, which are expressed from one parental allele only as a consequence of germline epigenetic events. The importance of epigenetic status of duplications at … Continue reading A study of genetic imprinting and neurodevelopmental disorders
This 2018 German rodent study was a proof-of-principle for immune epigenetic memory in the brain: “Innate immune memory is a vital mechanism of myeloid [bone marrow] cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished – training and tolerance. These are epigenetically … Continue reading Immune memory in the brain
This US 2018 review lead author was a gynecologic oncologist in private practice: “Sexual orientation is biologically conferred in the first trimester of pregnancy. Gender identity is biologically conferred during the middle trimester of pregnancy. Since the genitals differentiate in the first trimester, and the brain becomes imprinted in the latter half of gestation, it … Continue reading Are there epigenetic causes for sexual orientation and gender identity?
Ponder this drone photo of “a flying human tethered to a monkey” ground drawing made over 1,000 years ago as reported by National Geographic and excerpted by the Daily Star: Aren’t the geoglyph and its description pretty good expressions of our evolved condition? Especially since it’s the interpretation of people who lived more a millennium … Continue reading A flying human tethered to a monkey
Most of the spam I get on this blog comes in as ersatz comments on The hypothalamus couples with the brainstem to cause migraines. I don’t know what it is about the post that attracts internet bots. The unwanted attention is too bad because the post represents a good personal illustration of “changes in the … Continue reading How to cure the ultimate causes of migraines?
This 2016 German review was of the memory characteristics of immune cells: “Innate immune memory has likely evolved as an ancient mechanism to protect against pathogens. However, dysregulated processes of immunological imprinting mediated by trained innate immunity may also be detrimental under certain conditions. Evidence is rapidly accumulating that innate immune cells can adopt a … Continue reading Epigenetic remodeling creates immune system memory
This 2016 UK review subject was the interplay of genomic imprinting and intergenerational epigenetic information transfer: “A range of evolutionary adaptations associated with placentation transfers disproportionate control of this process to the matriline, a period unique in mammalian development in that there are three matrilineal genomes interacting in the same organism at the same time … Continue reading Contending with epigenetic consequences of violence to women
This 2015 review cited 143 studies to tie together findings in epigenetic chemistry and behavioral neuroscience. In addition to studies I’ve previously curated, other research included: a 2012 study which completely abolished mouse maternal behavior by silencing a gene encoding an estrogen receptor; a 2012 study which found that stress-induced changes in the rat hippocampus … Continue reading Epigenetic changes in the developing brain change behavior