Genetic imprinting, sleep, and parent-offspring conflict

This 2016 Italian review subject was the interplay of genetic imprinting and sleep regulation: “Sleep results from the synergism between at least two major processes: a homeostatic regulatory mechanism that depends on the accumulation of the sleep drive during wakefulness, and a circadian self-sustained mechanism that sets the time for sleeping and waking throughout the … Continue reading Genetic imprinting, sleep, and parent-offspring conflict

A study of genetic imprinting and neurodevelopmental disorders

This 2016 UK human study assessed the roles of genetic imprinting on diseases that may originate from a certain interval on chromosome 15: “The 15q11.2-q13.3 region contains a cluster of imprinted genes, which are expressed from one parental allele only as a consequence of germline epigenetic events. The importance of epigenetic status of duplications at … Continue reading A study of genetic imprinting and neurodevelopmental disorders

Epigenetic remodeling creates immune system memory

This 2016 German review was of the memory characteristics of immune cells: “Innate immune memory has likely evolved as an ancient mechanism to protect against pathogens. However, dysregulated processes of immunological imprinting mediated by trained innate immunity may also be detrimental under certain conditions. Evidence is rapidly accumulating that innate immune cells can adopt a … Continue reading Epigenetic remodeling creates immune system memory

Contending with epigenetic consequences of violence to women

This 2016 UK review subject was the interplay of genomic imprinting and intergenerational epigenetic information transfer: “A range of evolutionary adaptations associated with placentation transfers disproportionate control of this process to the matriline, a period unique in mammalian development in that there are three matrilineal genomes interacting in the same organism at the same time … Continue reading Contending with epigenetic consequences of violence to women

Epigenetic changes in the developing brain change behavior

This 2015 review cited 143 studies to tie together findings in epigenetic chemistry and behavioral neuroscience. In addition to studies I’ve previously curated, other research included: a 2012 study which completely abolished mouse maternal behavior by silencing a gene encoding an estrogen receptor; a 2012 study which found that stress-induced changes in the rat hippocampus … Continue reading Epigenetic changes in the developing brain change behavior

Epigenetic DNA methylation and demethylation with the developing fetus

This extremely dense and informative 2014 UK summary study provided details about genomic imprinting: “An unusual epigenetic process in that it is heritable and results in autosomal gene expression according to parent of origin.” Several notes of interest: The term “demethylation” occurred in the study 17 times, and should inform those who argue that epigenetic … Continue reading Epigenetic DNA methylation and demethylation with the developing fetus

One way that mothers cause fear and emotional trauma in their infants

This 2014 rodent study showed that infants learned to fear specific items in the environment that their mothers feared. The imprinting memory happened at a stage in the infants’ lives when they hadn’t yet developed the physiology to respond to the environment with fear on their own. The learning cue was the mothers’ fear response … Continue reading One way that mothers cause fear and emotional trauma in their infants