Genomic imprinting and growth

This 2018 UK paper reviewed genomic imprinting: “Since their discovery nearly 30 years ago, imprinted genes have been a paradigm for exploring the epigenetic control of gene expression. Moreover, their roles in early life growth and placentation are undisputed. However, it is becoming increasingly clear that imprinted gene function has a wider role in maternal … Continue reading Genomic imprinting and growth

Genetic imprinting, sleep, and parent-offspring conflict

This 2016 Italian review subject was the interplay of genetic imprinting and sleep regulation: “Sleep results from the synergism between at least two major processes: a homeostatic regulatory mechanism that depends on the accumulation of the sleep drive during wakefulness, and a circadian self-sustained mechanism that sets the time for sleeping and waking throughout the … Continue reading Genetic imprinting, sleep, and parent-offspring conflict

A study of genetic imprinting and neurodevelopmental disorders

This 2016 UK human study assessed the roles of genetic imprinting on diseases that may originate from a certain interval on chromosome 15: “The 15q11.2-q13.3 region contains a cluster of imprinted genes, which are expressed from one parental allele only as a consequence of germline epigenetic events. The importance of epigenetic status of duplications at … Continue reading A study of genetic imprinting and neurodevelopmental disorders

Trapped, suffocating, unable to move – a Primal imprint

“The malady of needing to move constantly: organizing trips, making reasons to go here and there, and in general, keeping on the move..below all that movement is a giant, silent scream. The price we pay is never knowing our feelings or where they come from. We have the mechanism for our own liberation inside of … Continue reading Trapped, suffocating, unable to move – a Primal imprint

Epigenetic effects of breast cancer treatments

This 2018 UC San Diego review subject was the interplay between breast cancer treatments and their effects on aging: “Although current breast cancer treatments are largely successful in producing cancer remission and extending lifespan, there is concern that these treatments may have long lasting detrimental effects on cancer survivors, in part, through their impact on … Continue reading Epigenetic effects of breast cancer treatments

Epigenetic variations in metabolism

This 2018 German review was comprehensive for its subject, epigenetic control of variation and stochasticity in metabolic disease. I’ll focus on one aspect, phenotypic variation: “Phenotypic [Mendelian] variation can result both from gain- and loss-of-function mutations. Because of the extreme interconnectivity of cell regulatory networks, even at the cellular level, predicting the impact of a … Continue reading Epigenetic variations in metabolism

Starving awakens ancient parasite DNA within us

This 2018 Italian human cell study conducted a series of experiments on the effects of nutrient deprivation: “Reduced food intake, and in particular protein or amino acid (AA) restriction, extends lifespan and healthspan. We have previously shown that, in mammalian cells, deprivation of essential AAs (methionine/cysteine or tyrosine) leads to the transcriptional reactivation of integrated … Continue reading Starving awakens ancient parasite DNA within us

A dietary supplement that trains the innate immune system

This 2018 Netherlands review topic was the long-term epigenetic programming of the innate immune system: “Immunological memory has been classically described for the adaptive immune system, in which naive B and T lymphocytes develop antigen-specific, long-lasting memory cells after encountering a new antigen. Immunological memory is not an exclusive trait of lymphocytes. The function of … Continue reading A dietary supplement that trains the innate immune system

A seasonal epigenetic effect of conception on BMI

This 2018 Swiss human/rodent study found: “The presence of brown adipose tissue (BAT) and the season of conception are linked to BMI in humans. In mice, we demonstrate that cold exposure (CE) of males, but not females, before mating results in improved systemic metabolism and protection from diet-induced obesity of the male offspring. Adipose tissue … Continue reading A seasonal epigenetic effect of conception on BMI

The hypothalamus and aging

This 2018 Korean review discussed aspects of the hypothalamus and aging: “A majority of physiological functions that decline with aging are broadly governed by the hypothalamus, a brain region controlling development, metabolism, reproduction, circadian rhythm, and homeostasis. In addition, the hypothalamus is poised to connect the brain and the body so that the environmental information … Continue reading The hypothalamus and aging