Genomic imprinting and growth

This 2018 UK paper reviewed genomic imprinting: “Since their discovery nearly 30 years ago, imprinted genes have been a paradigm for exploring the epigenetic control of gene expression. Moreover, their roles in early life growth and placentation are undisputed. However, it is becoming increasingly clear that imprinted gene function has a wider role in maternal … Continue reading Genomic imprinting and growth

Genetic imprinting, sleep, and parent-offspring conflict

This 2016 Italian review subject was the interplay of genetic imprinting and sleep regulation: “Sleep results from the synergism between at least two major processes: a homeostatic regulatory mechanism that depends on the accumulation of the sleep drive during wakefulness, and a circadian self-sustained mechanism that sets the time for sleeping and waking throughout the … Continue reading Genetic imprinting, sleep, and parent-offspring conflict

A study of genetic imprinting and neurodevelopmental disorders

This 2016 UK human study assessed the roles of genetic imprinting on diseases that may originate from a certain interval on chromosome 15: “The 15q11.2-q13.3 region contains a cluster of imprinted genes, which are expressed from one parental allele only as a consequence of germline epigenetic events. The importance of epigenetic status of duplications at … Continue reading A study of genetic imprinting and neurodevelopmental disorders

Trapped, suffocating, unable to move – a Primal imprint

“The malady of needing to move constantly: organizing trips, making reasons to go here and there, and in general, keeping on the move..below all that movement is a giant, silent scream. The price we pay is never knowing our feelings or where they come from. We have the mechanism for our own liberation inside of … Continue reading Trapped, suffocating, unable to move – a Primal imprint

A review of fetal adverse events

This 2019 Australian review subject was fetal adversities: “Adversity during the perinatal period is a significant risk factor for the development of neurodevelopmental disorders long after the causative event. Despite stemming from a variety of causes, perinatal compromise appears to have similar effects on the developing brain, thereby resulting in behavioural disorders of a similar … Continue reading A review of fetal adverse events

Organismal aging and cellular senescence

I’ll curate this 2019 German review through its figures: “With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Figure 1. Current determinants and relevant open questions, marking the processes of aging and … Continue reading Organismal aging and cellular senescence

A strawman argument against epigenetic clocks

This 2019 review of epigenetic clocks by Washington cancer researchers repeatedly returned to an argument for randomness as a cause for aging and disease: “A time-dependent stochastic event process, like epigenetic drift, could lead to cancer formation through the accumulation of random epigenetic alterations that, through chance, eventually alter epigenetic driver gene expression leading to … Continue reading A strawman argument against epigenetic clocks

Epigenetic transgenerational inheritance extends to the great-great-grand offspring

This 2019 rodent study by the Washington State University labs of Dr. Michael Skinner continued to F4 generation great-great-grand offspring, and demonstrated that epigenetic inheritance mechanisms are similar to imprinted genes: “Epigenetic transgenerational inheritance potentially impacts disease etiology, phenotypic variation, and evolution. An increasing number of environmental factors from nutrition to toxicants have been shown … Continue reading Epigenetic transgenerational inheritance extends to the great-great-grand offspring

Reversing epigenetic T cell exhaustion

This 2019 worldwide discussion among 18 experts concerned T cell exhaustion: “‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Key questions remain about the potential to … Continue reading Reversing epigenetic T cell exhaustion

Transgenerational epigenetic inheritance of thyroid hormone sensitivity

My 500th curation is a 2019 Portuguese human study of Azorean islanders: “This study demonstrates a transgenerational epigenetic inheritance in humans produced by exposure to high TH [thyroid hormone] in fetal life, in the absence of maternal influences secondary to thyrotoxicosis. The inheritance is along the male line. The present work took advantage of the … Continue reading Transgenerational epigenetic inheritance of thyroid hormone sensitivity