This 2018 Loma Linda review subject was gestational hypoxia: “Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis … Continue reading The lack of oxygen’s epigenetic effects on a fetus
This 2015 Colorado rodent study found: “Maternal ADN [adiponectin, a hormone produced by fat cells, that regulates fat and glucose metabolism] supplementation reversed the adverse effects of maternal obesity on placental function and fetal growth. Babies of mothers with obesity and/or gestational diabetes mellitus (GDM) are often large at birth and have increased adiposity, which … Continue reading Countering the epigenetic effects of obese mothers on their fetuses
This extremely dense and informative 2014 UK summary study provided details about genomic imprinting: “An unusual epigenetic process in that it is heritable and results in autosomal gene expression according to parent of origin.” Several notes of interest: Figure 3 had a fascinating sketch of how the fetus caused the mother’s hypothalamus to: “Determine forward … Continue reading Epigenetic DNA methylation and demethylation with the developing fetus
This 2014 rodent study was of polycystic ovarian syndrome, which is the leading cause of human female infertility. The researchers could reliably induce this disease in mice while they were still fetuses, but effects didn’t manifest until adulthood! The inducement method exposed the developing female fetuses to androgens such that their testosterone concentration was significantly … Continue reading Sex hormone exposure to the developing female fetus causes infertility in adulthood
Continuing Part 1 by curating a partial outline of a 2021 review: “This review focuses on the biological and beneficial effects of dietary betaine (trimethylglycine), a naturally occurring and crucial methyl donor. Betaine has a neuroprotective role, preserves myocardial function, and prevents pancreatic steatosis. Betaine also attenuates oxidant stress, endoplasmic reticulum stress, inflammation, and cancer … Continue reading All about the betaine, Part 2
A 2021 human study investigated sulforaphane treatments of autistic 3-to-12-year-olds: “Sulforaphane (SF) led to non-statistically significant changes in the total and all subscale scores of the primary outcome measure. Several effects of SF on biomarkers correlated to clinical improvements. SF was very well tolerated and safe and effective based on our secondary clinical measures. Clinical … Continue reading Does sulforaphane treat autism?
“May you always know the truth And see the light surrounding you May you always be courageous Stand upright and be strong May you have a strong foundation When the winds of changes shift May your heart always be joyful May your song always be sung And may you stay forever young” Sang this many … Continue reading Grow up to be true
This 2021 review subject was a measurable aspect of our early lives: “The first 1000 days from conception are a sensitive period for human development programming. During this period, environmental exposures may result in long-lasting epigenetic imprints that contribute to future developmental trajectories. The present review reports on effects of adverse and protective environmental conditions … Continue reading Our first 1000 days
This 2020 chicken study investigated the capability of nano-sulforaphane to protect embryonic survival and neurogenesis from a barbecued meat chemical: “Common teratogenic [of, relating to, or causing malformations of an embryo or a fetus] factors related to the development of the nervous system, such as alcohol consumption and smoking, have attracted wide attention. Teratogenic factors … Continue reading Nano-sulforaphane vs. barbecue chemicals
This 2020 review attempted to consolidate thousands of research papers on oxytocin: “Chemical properties of oxytocin make this molecule difficult to work with and to measure. Effects of oxytocin are context-dependent, sexually dimorphic, and altered by experience. Its relationship to a related hormone, vasopressin, have created challenges for its use as a therapeutic drug. Widely … Continue reading Unraveling oxytocin – is it nature’s medicine?
To better understand our internal origins of panic, here’s Dr. Arthur Janov’s interpretation of a 2013 Iowa study Fear and panic in humans with bilateral amygdala damage (not freely available): “Justin Feinstein did a study with those who had a damaged amygdala, the hub of the emotional system. They did not have normal fear responses. … Continue reading Flatten the Panic Curve April 13-17, 2020
This 2019 McGill review discussed long-lasting effects of perinatal stress: “Epigenetic processes are involved in embedding the impact of early-life experience in the genome and mediating between social environments and later behavioral phenotypes. Since these phenotypes are apparent a long time after early experience, changes in gene expression programming must be stable. Although loss of … Continue reading The epigenetics of perinatal stress
This 2019 Australian review subject was fetal adversities: “Adversity during the perinatal period is a significant risk factor for the development of neurodevelopmental disorders long after the causative event. Despite stemming from a variety of causes, perinatal compromise appears to have similar effects on the developing brain, thereby resulting in behavioural disorders of a similar … Continue reading A review of fetal adverse events
My 500th curation is a 2019 Portuguese human study of Azorean islanders: “This study demonstrates a transgenerational epigenetic inheritance in humans produced by exposure to high TH [thyroid hormone] in fetal life, in the absence of maternal influences secondary to thyrotoxicosis. The inheritance is along the male line. The present work took advantage of the … Continue reading Transgenerational epigenetic inheritance of thyroid hormone sensitivity
This 2019 Washington rodent study from Dr. Michael Skinner’s lab found adverse effects in the grand-offspring and great-grand-offspring following their ancestor’s exposure during pregnancy to the world’s most commonly used herbicide: “Using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation … Continue reading The transgenerational impact of Roundup exposure