This 2020 paper reviewed hormetic effects of a broccoli sprout compound: “Sulforaphane (SFN) induces a broad spectrum of chemoprotective effects across multiple organs that are of importance to public health and clinical medicine. This chemoprotection is dominated by hormetic dose responses that are mediated by the Nrf2/ARE pathway and its complex regulatory interactions with other … Continue reading Sulforaphane in the Goldilocks zone
This 2019 US rodent study concerned transmitting poor maternal care to the next generation: “The quality of parental care received during development profoundly influences an individual’s phenotype, including that of maternal behavior. Infant experiences with a caregiver have lifelong behavioral consequences. Maternal behavior is a complex behavior requiring the recruitment of multiple brain regions including … Continue reading A drug that countered effects of a traumatizing mother
This 2018 review presented evidence that: “For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. However, there is an increasing understanding that the mechanisms … Continue reading Disproving the cholesterol paradigm
The principal way science advances is through a principle Einstein expressed as: “No amount of experimentation can ever prove me right; a single experiment can prove me wrong.” The scientific community and public should be satisfied that the scientific process is working well when hypotheses are discarded due to nonconfirming evidence. Researchers should strive to … Continue reading A disturbance in the paradigm of child abuse
Two items before getting to the review: 94% of rodent genera are naturally uniparental; The Rattus and Mus genera used in almost all rodent research aren’t part of the 6% in which fathers also provide offspring care. This 2018 Australian review subject was paternal intergenerational and transgenerational transmission of biological and behavioral phenotypes per this … Continue reading How well do single-mother rodent studies inform us about human fathers?
This 2017 UK/Spanish review subject was biological variability: “No two cells in a cellular population are the same, and no two individuals of a multi-cellular species are identical-not even if they share the same genetic makeup like monozygotic twins or cloned animals. Epigenetic and gene expression variability are key contributors to phenotypic differences. There are … Continue reading A review of biological variability
This 2016 New York rodent study found: “Parental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. We show that four anxiety/stress-reactive traits are transmitted via independent iterative-somatic and gametic epigenetic mechanisms across multiple generations. As the individual traits/pathways each have their own generation-dependent penetrance and gender specificity, the resulting cumulative phenotype is … Continue reading A limited study of parental transmission of anxiety/stress-reactive traits
This 2016 UK review subject was the interplay of genomic imprinting and intergenerational epigenetic information transfer: “A range of evolutionary adaptations associated with placentation transfers disproportionate control of this process to the matriline, a period unique in mammalian development in that there are three matrilineal genomes interacting in the same organism at the same time … Continue reading Contending with epigenetic consequences of violence to women
This 2016 review by Eric Nestler, a well-known and well-funded researcher, entitled Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction? concluded: “Further work is needed to understand whether and to what extent true epigenetic inheritance of stress vulnerability adds to the well-established and powerful influence of genetics and environmental exposures in determining an individual’s … Continue reading What is epigenetic inheritance?
As an adult, what would be your primary concern if you suspected that your early life had something to do with current problems? Would you be interested in effective treatments for causes of your symptoms? Such information wasn’t available in this 2016 Miami review of the effects of child abuse. The review laid out the … Continue reading The current paradigm of child abuse limits pre-childhood causal research
I curated this 2013 study because one of the authors has made a career out of denying that people accurately remember and re-experience emotional memories. I’ll show how this viewpoint created problems with the study. For background, one relevant hypothesis of Dr. Arthur Janov’s Primal Therapy is that there are differences in the levels of … Continue reading Agenda-driven research on emotional memories