Precondition your defenses with broccoli sprouts

This 2020 human cell study elaborated on mechanisms mentioned in Eat broccoli sprouts for your hearing and Sulforaphane in the Goldilocks zone: “NFE2L2/NRF2, a transcriptional factor that controls expression of multiple detoxifying enzymes through antioxidant response elements (AREs), is a target of sulforaphane (SFN). NFE2L2/NRF2 is a target gene of TFEB (transcription factor EB), a … Continue reading Precondition your defenses with broccoli sprouts

Broccoli sprouts positively influence Sestrin proteins

Four papers on Sestrin, with the first a 2021 review: “Sestrin 2 (Sesn2) is a member of the evolutionarily conserved and stress-inducible sestrin family. In mammals, this family is composed of Sesn1–3, and Sesn2 is the main member that responds to oxidative stress. Sesn2 inhibits mammalian target of rapamycin (mTOR)-mediated cell over-proliferation by activating adenosine … Continue reading Broccoli sprouts positively influence Sestrin proteins

Eat broccoli sprouts for your hearing

Two 2021 papers, both of which I found by each citing a 2009 Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane (not freely available). First was a review: “Hair cell damage and loss mediated by oxidative stress are important causes of hearing loss. Sensorineural hearing loss is the … Continue reading Eat broccoli sprouts for your hearing

Part 2 of Broccoli sprouts activate the AMPK pathway

This 2021 review subject was metformin’s role in autophagy: “Metformin had been used as the first choice for treating diabetes for almost a century. Autophagy is responsible for recycling and degrading cellular components, which significantly affects cell functions in physiology and pathology. Effects of metformin on autophagy mainly depend on corresponding signaling pathways in specific … Continue reading Part 2 of Broccoli sprouts activate the AMPK pathway

Oat β-glucan effects on colitis

This 2021 rodent study investigated oat β-glucan effects on colitis: “In this study, we determined effects of consumption of low- and high-molar-mass oat beta-glucans on expression of selected markers of apoptosis and autophagy in colonocytes in TNBS colitis-induced rats. We analyzed expression of colon wall receptors, including TLRs and Dectin-1, which are involved in recognition … Continue reading Oat β-glucan effects on colitis

Part 2 of Eat broccoli sprouts for your eyes

I was a little bothered by an unreferenced statement in Eat broccoli sprouts for your eyes that: “Once AGEs are formed, most are irreversible.” I searched curated 2020 studies for “revers” and found that recent blog studies favored reversibility of epigenetic changes 12-to-2. Do they reflect my selection bias, or is there something different about … Continue reading Part 2 of Eat broccoli sprouts for your eyes

Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Reversal of aging and immunosenescent trends with sulforaphane

Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane

Linking adult neurogenesis to Alzheimer’s disease

This 2019 Spanish human study compared DNA methylation, chromatin and histone modifications in the hippocampus of deceased Alzheimer’s disease patients with controls: “A significant percentage of the differentially methylated genes were related to neural development and neurogenesis. It was astounding that other biological, cellular, and molecular processes generally associated with neurodegeneration such as apoptosis, autophagy, … Continue reading Linking adult neurogenesis to Alzheimer’s disease

Lack of oxygen’s epigenetic effects

This 2016 Finnish review subject was epigenetic effects of hypoxia: “Ever since the Cambrian period, oxygen availability has been in the center of energy metabolism. Hypoxia stabilizes expression of hypoxia-inducible transcription factor-1α (HIF-1α), which controls expression of hundreds of survival genes related to enhanced energy metabolism and autophagy. There are several other signals, mostly related … Continue reading Lack of oxygen’s epigenetic effects

The hypothalamus’ role in how calorie restriction delays aging

This 2015 Portuguese rodent study showed the underlying mechanism to explain why restricting calories delays aging. A calorie reduction of 20 to 40% increased production of a normally occurring molecule (neuropeptide Y) in the hypothalamus part of the limbic system. The increased amounts of the molecule stimulated autophagy (the breakdown and recycling of cellular components) … Continue reading The hypothalamus’ role in how calorie restriction delays aging