Broccoli sprouts activate the AMPK pathway, Part 4

Today someone viewed the 2020 Part 3 of Broccoli sprouts activate the AMPK pathway which lacked citations at the time. Checking again, here are three citing 2022 papers, starting with a review: “Nrf2 is an important transcription factor that regulates expression of a large number of genes in healthy and disease states. Nrf2 regulates expression … Continue reading Broccoli sprouts activate the AMPK pathway, Part 4

Exercise substitutes?

Two papers, starting with a 2022 abstract of an ongoing in vitro study with rodent cells: “Exercise mimetics may target and activate the same mechanisms that are upregulated with exercise administration alone. This is particularly useful under conditions where contractile activity is compromised due to muscle disuse, disease, or aging. Sulforaphane and Urolithin A represent … Continue reading Exercise substitutes?

Young immune system, young brain

This 2022 study investigated brain aging: “We aimed to explore key genes underlying cognitively normal brain aging and its potential molecular mechanisms. Cellular and molecular mechanisms of brain aging are complex and mainly include: Dysfunction of mitochondria; Accumulation of oxidatively damaged proteins, nucleic acids, and lipids in brain cells; Disorders of energy metabolism; Impaired ‘waste … Continue reading Young immune system, young brain

Sulforaphane vs. too much oxygen

This 2021 rodent study investigated perinatal effects of hyperoxia and sulforaphane: “We demonstrated that early-life oxidant-induced acute lung injury had significant consequences later in life on NRF2-dependent respiratory syncytial virus (RSV) susceptibility in mice. We also determined that increased antioxidant conditions in utero potentially contribute to a decreased risk of postnatal airway disease as we … Continue reading Sulforaphane vs. too much oxygen

Natural products vs. neurodegenerative diseases

I was recently asked about taking rapamycin for its effects on mTOR. I replied that diet could do the same thing. Here’s a 2021 review outlining such effects: “As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available. Recent studies have revealed … Continue reading Natural products vs. neurodegenerative diseases

Precondition your defenses with broccoli sprouts

This 2020 human cell study elaborated on mechanisms mentioned in Eat broccoli sprouts for your hearing and Sulforaphane in the Goldilocks zone: “NFE2L2/NRF2, a transcriptional factor that controls expression of multiple detoxifying enzymes through antioxidant response elements (AREs), is a target of sulforaphane (SFN). NFE2L2/NRF2 is a target gene of TFEB (transcription factor EB), a … Continue reading Precondition your defenses with broccoli sprouts

Broccoli sprouts positively influence Sestrin proteins

Four papers on Sestrin, with the first a 2021 review: “Sestrin 2 (Sesn2) is a member of the evolutionarily conserved and stress-inducible sestrin family. In mammals, this family is composed of Sesn1–3, and Sesn2 is the main member that responds to oxidative stress. Sesn2 inhibits mammalian target of rapamycin (mTOR)-mediated cell over-proliferation by activating adenosine … Continue reading Broccoli sprouts positively influence Sestrin proteins

Eat broccoli sprouts for your hearing

Two 2021 papers, both of which I found by each citing a 2009 Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane (not freely available). First was a review: “Hair cell damage and loss mediated by oxidative stress are important causes of hearing loss. Sensorineural hearing loss is the … Continue reading Eat broccoli sprouts for your hearing

Part 2 of Broccoli sprouts activate the AMPK pathway

This 2021 review subject was metformin’s role in autophagy: “Metformin had been used as the first choice for treating diabetes for almost a century. Autophagy is responsible for recycling and degrading cellular components, which significantly affects cell functions in physiology and pathology. Effects of metformin on autophagy mainly depend on corresponding signaling pathways in specific … Continue reading Part 2 of Broccoli sprouts activate the AMPK pathway

Oat β-glucan effects on colitis

This 2021 rodent study investigated oat β-glucan effects on colitis: “In this study, we determined effects of consumption of low- and high-molar-mass oat beta-glucans on expression of selected markers of apoptosis and autophagy in colonocytes in TNBS colitis-induced rats. We analyzed expression of colon wall receptors, including TLRs and Dectin-1, which are involved in recognition … Continue reading Oat β-glucan effects on colitis

Part 2 of Eat broccoli sprouts for your eyes

I was a little bothered by an unreferenced statement in Eat broccoli sprouts for your eyes that: “Once AGEs are formed, most are irreversible.” I searched curated 2020 studies for “revers” and found that recent blog studies favored reversibility of epigenetic changes 12-to-2. Do they reflect my selection bias, or is there something different about … Continue reading Part 2 of Eat broccoli sprouts for your eyes

Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Reversal of aging and immunosenescent trends with sulforaphane

Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane

Linking adult neurogenesis to Alzheimer’s disease

This 2019 Spanish human study compared DNA methylation, chromatin and histone modifications in the hippocampus of deceased Alzheimer’s disease patients with controls: “A significant percentage of the differentially methylated genes were related to neural development and neurogenesis. It was astounding that other biological, cellular, and molecular processes generally associated with neurodegeneration such as apoptosis, autophagy, … Continue reading Linking adult neurogenesis to Alzheimer’s disease

Lack of oxygen’s epigenetic effects

This 2016 Finnish review subject was epigenetic effects of hypoxia: “Ever since the Cambrian period, oxygen availability has been in the center of energy metabolism. Hypoxia stabilizes expression of hypoxia-inducible transcription factor-1α (HIF-1α), which controls expression of hundreds of survival genes related to enhanced energy metabolism and autophagy. There are several other signals, mostly related … Continue reading Lack of oxygen’s epigenetic effects