A 2021 human study investigated sulforaphane treatments of autistic 3-to-12-year-olds: “Sulforaphane (SF) led to non-statistically significant changes in the total and all subscale scores of the primary outcome measure. Several effects of SF on biomarkers correlated to clinical improvements. SF was very well tolerated and safe and effective based on our secondary clinical measures. Clinical … Continue reading Does sulforaphane treat autism?
This 2020 US human study investigated autism improvements with sulforaphane: “Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders that, in the United States, is currently estimated to affect 1 out of 59 children who are 8 years old. Despite decades of research and advances in our knowledge of etiologies of ASD, … Continue reading Autism biomarkers and sulforaphane
This 2016 New York human study found: “Measurement of salivary miRNA in this pilot study of subjects with mild ASD [autism spectrum disorder] demonstrated differential expression of 14 miRNAs that are: expressed in the developing brain, impact mRNAs related to brain development, and correlate with neurodevelopmental measures of adaptive behavior.” Some problems with current diagnostic … Continue reading Using salivary microRNA to diagnose autism
A 2015 case study by Ohio physicians highlighted: “Although only a small minority of patients with autism have a mitochondrial disease, many patients with mitochondrial myopathies have autism spectrum disorder symptoms. These symptoms may be the presenting symptoms, which presents a diagnostic challenge for clinicians. The case of a 15-year-old boy with a history of … Continue reading Where do our beliefs about our children come from? An autism example
This 2015 Chicago review noted: “Recent developments in the research of ASD [autistic spectrum disorder] with a focus on epigenetic pathways as a complement to current genetic screening. Not all children with a predisposing genotype develop ASD. This suggests that additional environmental factors likely interact with the genome in producing ASD. Increased risk of ASD … Continue reading A review of genetic and epigenetic approaches to autism
This 2014 Stanford human study found: “No empirical support for the OXT [oxytocin] deficit hypothesis of ASD [autism spectrum disorder], nor did plasma OXT concentrations differ by sex, OXTR [oxytocin receptor] SNPs [single nucleotide polymorphisms], or their interactions.” Apparently, there was a: “Prevalent but not well-interrogated OXT deficit hypothesis of ASD.” The researchers followed up … Continue reading A mixed bag of findings about oxytocin, its receptor, and autism
This 2013 study: “Examined whether genetic variants of the OXTR [oxytocin receptor] affect face recognition memory in families with an autistic child. We investigated whether common polymorphisms in the genes encoding the oxytocin and vasopressin 1a receptors influence social memory for faces.” I feel that the researchers missed an opportunity to improve their assessment of … Continue reading A missed opportunity to research the oxytocin receptor gene and autism
Three papers on gut barriers, with the first a 2020 review of four intestinal barrier layers: “The epithelial cell layer and outer/inner mucin layer constitute the physical barrier. Intestinal alkaline phosphatase (IAP) produced by epithelial cells and antibacterial proteins secreted by Panneth cells represent the functional barrier. Multiple layers of this barrier, from intestinal lumen … Continue reading Improving gut barriers
This 2020 paper reviewed hormetic effects of a broccoli sprout compound: “Sulforaphane (SFN) induces a broad spectrum of chemoprotective effects across multiple organs that are of importance to public health and clinical medicine. This chemoprotection is dominated by hormetic dose responses that are mediated by the Nrf2/ARE pathway and its complex regulatory interactions with other … Continue reading Sulforaphane in the Goldilocks zone
This 2020 Swiss review subject was the interaction of Nrf2 activators and skin: “The electrophile and Nrf2 activator dimethyl fumarate (DMF) is an established and efficient drug for patients suffering from the common inflammatory skin disease psoriasis. DMF is being tested for pharmacological activity in several other inflammatory skin conditions. Psoriasis is a chronic inflammatory … Continue reading Eat broccoli sprouts for your skin!
This 2020 Polish study investigated dried broccoli sprouts characteristics: “The aim of this study was to quantify the air-drying and freeze-drying kinetics of broccoli sprouts. The Page model exhibited a very good fit to experimental data obtained by both air-drying and freeze-drying techniques. Time of germination had less effect on drying kinetics of broccoli sprouts. … Continue reading Drying broccoli sprouts
Armando asked a good question in Upgrade your brain’s switchboard with broccoli sprouts: “Is there any way to consume sulphorafane in a supplement form? Rather than have to jump so many hops to consume it from broccoli.” That blog post referenced a 2017 study, whose sulforaphane amount was: “100 µmol [17.3 mg] sulforaphane as standardized … Continue reading Are sulforaphane supplements better than microwaved broccoli sprouts?
This 2016 Georgia human study found: “A role for OXTR [oxytocin receptor gene] in understanding the influence of early environments on adult psychiatric symptoms. Data on 18 OXTR CpG sites, 44 single nucleotide polymorphisms, childhood abuse, and adult depression and anxiety symptoms were assessed in 393 African American adults. The Childhood Trauma Questionnaire (CTQ), a … Continue reading A problematic study of oxytocin receptor gene methylation, childhood abuse, and psychiatric symptoms
Neuroskeptic’s blog post Genetic Testing for Autism as an Existential Question related the story of “A Sister, a Father and a Son: Autism, Genetic Testing, and Impossible Decisions.” “I decided to put the question to my sister, Maria. Although she is autistic, she is of high intelligence. Maria was excited to be an aunt soon, … Continue reading What was not, is not, and will never be
This 2015 New York human study was of: “The two major populations of human prefrontal cortex neurons..the excitatory glutamatergic projection neurons and the inhibitory GABAergic interneurons which constitute about 80% and 20% of all cortical neurons, respectively. Major differences between the neuronal subtypes were revealed in CpG, non-CpG and hydroxymethylation (hCpG). A dramatically greater number … Continue reading Improved methodology in studying epigenetic DNA methylation