Search Results for: allostatic

Epigenetic effects of early life stress exposure

gettingwell4 5+ stars Premium, Amygdala, Anterior cingulate cortex, Brain development, Brainstem, Cerebrum, Cortisol, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Locus coeruleus, Lower brain, Memory, Neurochemicals, Serotonin, Stress, Thalamus, Vasopressin , , , , , , , , , ,

This 2017 Netherlands review subject was the lasting epigenetic effects of early-life stress: “Exposure to stress during critical periods in development can have severe long-term consequences. One of the key stress response systems mediating these long-term effects of stress is the hypothalamic-pituitary-adrenal (HPA) axis. Early life stress (ELS) exposure has been reported to have numerous … Continue reading Epigenetic effects of early life stress exposure

How one person’s paradigms regarding stress and epigenetics impedes relevant research

gettingwell4 < 0 Detracted from science, Amygdala, Beliefs, Brain development, Brainstem, Cerebrum, Cortisol, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Locus coeruleus, Lower brain, Memory, Neurochemicals, Serotonin, Stress, Testosterone , , , , , , , , , ,

This 2017 review laid out the tired, old, restrictive guidelines by which current US research on the epigenetic effects of stress is funded. The reviewer rehashed paradigms circumscribed by his authoritative position in guiding funding, and called for more government funding to support and extend his reach. The reviewer won’t change his beliefs regarding individual … Continue reading How one person’s paradigms regarding stress and epigenetics impedes relevant research

Mitochondria interface genetic/epigenetic responses to psychological stress

gettingwell4 2-3 stars Needed further work, Cortisol, Dopamine, Epigenetics, Glutamate, Hippocampus, Hypothalamus, Limbic system, Neurochemicals, Serotonin, Stress , , , ,

This 2015 Pennsylvania rodent study found: “Mitochondria can regulate complex whole-body physiological responses, impacting stress perception at the cellular and organismal levels. Mitochondrial dysfunctions altered the hypothalamic–pituitary–adrenal [HPA] axis, sympathetic adrenal–medullary activation and catecholamine levels, the inflammatory cytokine IL-6, circulating metabolites, and hippocampal gene expression responses to stress. Stress-induced neuroendocrine, inflammatory, metabolic, and transcriptional responses … Continue reading Mitochondria interface genetic/epigenetic responses to psychological stress

Is it science, or is it a silly and sad farce when researchers “make up” missing data?

gettingwell4 < 0 Detracted from science, Brain development, Epigenetics, Hippocampus, Limbic system, Stress , , , ,

This 2014 French study was a parody of science. The researchers “made up” missing data on over 50% of the men and over 47% of the women! All to satisfy their model that drove an agenda of the effects of adverse childhood experiences. As an example of how silly and sad this was: Two of … Continue reading Is it science, or is it a silly and sad farce when researchers “make up” missing data?

Problematic research on stress that will never make a contribution toward advancing science

gettingwell4 < 0 Detracted from science, Cortisol, Neurochemicals, Stress

This 2014 UK human study found: “Type 2 diabetes is characterized by disruption of stress-related processes across multiple biological systems and increased exposure to life stress.” HOWEVER, the stress effects weren’t conclusively shown to be either a cause or consequence of type 2 diabetes. Correlation wasn’t causation. Looking around for clues as to what went … Continue reading Problematic research on stress that will never make a contribution toward advancing science

Shorter telomere length in older men but not older women

gettingwell4 2-3 stars Needed further work, Cortisol, Immune system, Neurochemicals, Stress, Telomeres

This 2014 UK human study was the first on telomere length I’ve curated, so here’s some background information: “Telomeres are..structures..that cap the ends of..chromosomes, protecting them from end-to-end fusion and degradation during cell division. Human telomeric DNA naturally shortens with age during..cell divisions and as a result of oxidative attack. At critical shortness, telomeres exhibit … Continue reading Shorter telomere length in older men but not older women