Two reviews of Nrf2 relationships with our two immune systems, starting with adaptive immunity: “We highlight recent findings about the influence of Keap1 and Nrf2 in development and effector functions of adaptive immune cells, T lymphocytes and B lymphocytes. We summarize Nrf2 research potential and targetability for treating immune pathologies. Immune cells have mechanisms in … Continue reading Nrf2 Week #7: Immunity
Three papers on sulforaphene, starting with a 2022 in vitro digestion study by Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts group: “This work aims to assess anti-inflammatory potential of bioactive compounds of cruciferous sprouts red radish (RRS) and red cabbage (RCS) in their bioaccessible form (obtained by the digestion of … Continue reading Sulforaphene, a natural analog of sulforaphane
Here are six 2022 papers that either cited the second study of Variable aging measurements, or provided further evidence for its findings. Let’s start with a citing study: “This study aimed to investigate expression patterns and prognostic values of the inflammatory aging clock (iAge) in glioblastoma (GBM), and its relations with stem cells. Similar to … Continue reading An inflammation clock
This 2022 rodent cell study used the natural form of sulforaphane to replicate experiments performed with mixtures of its natural and unnatural forms: “Natural sulforaphane (SFN) exists as a single enantiomer with a RS absolute configuration. Most studies focusing on its biological activities, in particular its anti-inflammatory and antioxidant activities, have been conducted using its … Continue reading Natural sulforaphane effects
To follow up Is boron important to health? I’ll highlight a 2022 review of boron intake: “Boron is essential for activity of several metabolic enzymes, hormones, and micronutrients. It is important for growth and maintenance of bone, reduction in inflammatory biomarkers, and increasing levels of antioxidant enzymes. The average person’s daily diet contains 1.5 to … Continue reading Non-patentable boron benefits
This 2022 rodent study investigated effects of glucoraphanin supplementation during pregnancy and lactation: “We investigated whether dietary intake of sulforaphane glucosinolate (SGS [properly termed glucoraphanin]) during pregnancy and lactation influenced composition of gut microbiota in offspring: Dietary intake of SGS during pregnancy and lactation caused significant changes in diversity of gut microbiota in 3-week-old offspring … Continue reading Eat broccoli sprouts for your offspring
Two papers on aging measurements, starting with a 2022 human study: “We collected longitudinally across the adult age range a comprehensive list of phenotypes within four domains (body composition, energetics, homeostatic mechanisms and neurodegeneration / neuroplasticity) and functional outcomes. We integrated individual deviations from population trajectories into a global longitudinal phenotypic metric of aging. We … Continue reading Variable aging measurements
Two 2022 papers, starting with a review of sulforaphane’s effects on intestinal inflammation: “This review summarizes characteristics of intestinal inflammation, the anti-inflammatory mechanism of sulforaphane (SFN) and its various protective effects on intestinal inflammation, and possible future applications of SFN for promoting intestinal health. SFN is an effective agonist of Nrf2, and it is also … Continue reading Eat broccoli sprouts for your gut
This 2021 rodent study investigated dietary advanced glycation end products (AGEs): “There is increasing evidence in humans and animals that consumption of dietary AGEs contribute to AGEs measured in plasma and organs and that a diet high in dietary AGEs in humans has negative biological effects, such as low-grade inflammation, endothelial dysfunction, and insulin resistance. … Continue reading Reversibility of AGEs concentrations
This 2022 study investigated biological mechanisms of aging: “Age-related multimorbidity, the presence of more than one age-related disease (ARD) in an individual, poses a major and increasing challenge. Open questions are whether mechanisms of aging can explain ARD co-occurrence in patients, and whether intervention into these mechanisms could prevent or treat multiple ARDs simultaneously. Five … Continue reading Signaling pathways and aging
Two 2022 in vitro studies from the group that published Red cabbage effects on gut microbiota, with the first nanoencapsulating sulforaphane: “Sulforaphane (SFN) loaded into membrane vesicles derived from broccoli plants was studied to determine anti-inflammatory potential in a human-macrophage-like in vitro cell model under both normal and inflammatory conditions. LPS increased IL-6 levels 1.86-fold. … Continue reading Nanoencapsulating Brassica bioactives with Brassica membrane vesicles
I’ll highlight this 2022 review’s relationships between inflammation and cluster of differentiation 38: “We review the nicotinamide adenine dinucleotide (NAD) catabolizing enzyme CD38, which plays critical roles in pathogenesis of diseases related to infection, inflammation, fibrosis, metabolism, and aging. NAD is a cofactor of paramount importance for an array of cellular processes related to mitochondrial … Continue reading CD38 and balance
This 2021 human cell study investigated trained immunity responses: “We integrated genetic, epigenetic, and functional validation data to shed light on regulation of trained immunity responses. This data integration revealed a novel role of SIGLECs and KDM4 genes on trained immunity responses. Siglec-5 is an inhibitory receptor that dampens the immune response, and was found … Continue reading Trained immunity genes
This week I dialed back eating microwaved 3-day-old broccoli / red cabbage / mustard sprouts from twice a day to once a day. For my reasoning, here are two papers on broccoli sprouts and thyroid function, with the first a 2018 human study: “We analyzed biochemical measures of thyroid function and thyroid autoimmunity in a … Continue reading Week 87 of Changing to a youthful phenotype with sprouts
This 2021 rodent study investigated sulforaphane pretreatment’s role in reducing liver injuries: “As a double blood supply organ of the portal vein and artery, the liver is highly sensitive to ischemia, and is one of the common organs to suffer from hepatic ischemia-reperfusion injury (HI/RI). HI/RI leads to overproduction of reactive oxygen species (ROS). Overdoses … Continue reading Eat broccoli sprouts for your liver
Surface Your Real Self 