Eat broccoli sprouts for DIM

This 2019 Spanish human study ran in parallel with Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts. I’ll focus on the aspect of diindolylmethane (DIM) from eating broccoli sprouts: “The aim of this study is to evaluate the effect of gender or hormonal status (menopause) on the bioavailability of broccoli … Continue reading Eat broccoli sprouts for DIM

Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Here are my Day 70 measurements* to follow up Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts, which had these findings: Keep in mind that I’m not in the population represented by the clinical trial sample: My chronological age is above their inclusion range; My BMI is below their inclusion … Continue reading Day 70 results from Changing to a youthful phenotype with broccoli sprouts

Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts

The further I get into a daily regimen of eating broccoli sprouts for ten weeks, the more I appreciate “Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects.” “This study represents an advance in intervention studies as the broccoli sprouts were included in a daily dietary pattern in quantities that reflect … Continue reading Our model clinical trial for Changing to a youthful phenotype with broccoli sprouts

Reversal of aging and immunosenescent trends with sulforaphane

Sulforaphane research findings have commonalities with a super informative presentation by the lead researcher of clinical trial Reversal of aging and immunosenescent trends. I did a PubMed search of sulforaphane and each presentation topic, and used a 1/1/2015 publication date cutoff. Presentation topics through the first 13 minutes were: Thymus – no recent sulforaphane studies … Continue reading Reversal of aging and immunosenescent trends with sulforaphane

Part 2 of Rejuvenation therapy and sulforaphane

A rejuvenation therapy and sulforaphane focused on the study’s clinical biomarkers and not its biological age measurements. This Part 2 curation of the study highlights its epigenetic clocks because: “While clinical biomarkers have obvious advantages (being indicative of organ dysfunction or disease), they are neither sufficiently mechanistic nor proximal to fundamental mechanisms of aging to … Continue reading Part 2 of Rejuvenation therapy and sulforaphane

An environmental signaling paradigm of aging

To follow up A rejuvenation therapy and sulforaphane, the study’s lead laboratory researcher provided evidence for an environmental signaling paradigm of aging in this 2015 paper: “The age-phenotype of a cell or organ depends on its environment and not its history. Organ dysfunction is not the cause of aging, but is the result of its … Continue reading An environmental signaling paradigm of aging

A rejuvenation therapy and sulforaphane

The founder of the epigenetic clock methodology with the coauthor of Aging as an unintended consequence released a 2020 rodent study “Reversing age: dual species measurement of epigenetic age with a single clock” at https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.pdf: “We employed six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. Two of … Continue reading A rejuvenation therapy and sulforaphane

Week 6 of Changing an inflammatory phenotype with broccoli sprouts

To follow up Week 5 of Changing an inflammatory phenotype with broccoli sprouts: 1. I had an informative exchange with an author of Microwave broccoli to increase sulforaphane levels. The study provided an optimal sulforaphane end result of “(2.45 µmol/g DW)”. I asked a study author for additional data, and they replied: “The control GLR … Continue reading Week 6 of Changing an inflammatory phenotype with broccoli sprouts

Broccoli sprouts oppose effects of advanced glycation end products (AGEs)

This 2020 Australian/UK review subject was AGEs: “AGEs are formed during cooking and food processing or produced endogenously as a consequence of metabolism. The deleterious effects of AGEs are underpinned by their ability to trigger mechanisms well known to elicit metabolic dysfunction, including the activation of inflammatory pathways, oxidative stress and impaired mitochondrial oxidative metabolism. … Continue reading Broccoli sprouts oppose effects of advanced glycation end products (AGEs)

Flatten the Panic Curve April 13-17, 2020

To better understand our internal origins of panic, here’s Dr. Arthur Janov’s interpretation of a 2013 Iowa study Fear and panic in humans with bilateral amygdala damage (not freely available): “Justin Feinstein did a study with those who had a damaged amygdala, the hub of the emotional system. They did not have normal fear responses. … Continue reading Flatten the Panic Curve April 13-17, 2020