I was recently asked about taking rapamycin for its effects on mTOR. I replied that diet could do the same thing. Here’s a 2021 review outlining such effects: “As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available. Recent studies have revealed … Continue reading Natural products vs. neurodegenerative diseases
This 2020 rodent study demonstrated benefits from daily cooked broccoli intake, even when it contained no myrosinase enzyme and no sulforaphane: “Broccoli consumption by rats influenced several metabolic pathways that impact liver health. Plasma metabolite changes are potential biomarkers of liver health, and also monitor broccoli benefits. Rats fed a broccoli diet exhibited an enhanced … Continue reading Eat broccoli sprouts every day
Two papers, starting with a 2021 meta-analysis of mushroom intake: “Mushroom consumption was associated with a lower risk of total mortality in this nationally representative sample of US adults. 15,546 participants were included, mean age 44.3 years. During a mean follow-up duration of 19.5 years, a total of 5,826 deaths were documented. Participants who reported … Continue reading Eat mushrooms for a longer life?
A trio of papers on ergothioneine starts with a 2019 human study. 3,236 people without cardiovascular disease and diabetes mellitus ages 57.4 ± 6.0 were measured for 112 metabolites, then followed-up after 20+ years: “We identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be … Continue reading The amino acid ergothioneine
This 2018 human study found: “The objective of this study was to determine whether daily broccoli consumption alters absorption and metabolism of isothiocyanates derived from broccoli glucosinolates. We conducted a randomised cross-over human study (n = 18) balanced for BMI and glutathione S-transferase μ 1 (GSTM1) genotype in which subjects consumed a control diet with … Continue reading Eat broccoli sprouts daily, and manage weight
1. Per Improving healthy compounds of broccoli sprouts and Broccoli sprouts’ immune effects, this week I added mustard sprouts and red cabbage sprouts to my twice-daily routine of eating 3-day-old microwaved broccoli sprouts. At first, I started mustard and red cabbage seeds with the same 10.7 gram weight (one tablespoon) of seeds. They grew well … Continue reading Week 56 of Changing to a youthful phenotype with sprouts
Two 2021 papers, with the first’s subject being sulforaphane’s immune effects: “Effects of sulforaphane (SFN) on immune response generate scientific interest because of its bioavailability, which is much higher than other phytochemicals, and its capacity to induce Nrf2 target genes. Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail. SFN … Continue reading Broccoli sprouts’ immune effects
This 2021 review summarized three dietary supplements’ effects on psychiatric symptoms: “Upregulation of Nrf2 has been suggested as a common therapeutic target for major neuropsychiatric disorders. In this paper, evidence is presented showing how NAC [N-acetyl-cysteine], coenzyme Q10 (CoQ), and melatonin can ameliorate many important effects of oxidative stress by upregulating Nrf2. Given its key … Continue reading Several diseases, one treatment?
This 2021 rodent study found: “We show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to expansion of taxa that utilize taurine. Supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Taurine … Continue reading Train your gut microbiota with taurine
Starting Year 7 of curating research with a 2021 review of kidney disease and sulforaphane: “Many chronic kidney disease (CKD) patients progress to end-stage kidney disease – the ultimate in failed prevention. While increased oxidative stress is a major molecular underpinning of CKD progression, no treatment modality specifically targeting oxidative stress has been established clinically. … Continue reading Eat broccoli sprouts for your kidneys
This 2019 article was by the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. It isn’t widely available, so I’ll quote liberally: “Demand for solutions to digestive health issues is accelerating, especially since both scientific literature and popular press dedicate significant resources to … Continue reading Harnessing endogenous defenses with broccoli sprouts
To follow up topics of Part 1‘s interview: 1. “We each have a unique microbial signature in the gut. Metabolites that you produce might not be the same ones that I produce. This makes clinical studies very difficult because you don’t have a level playing field.” This description of inter-individual variability could inform researchers’ investigations … Continue reading Part 2 of Switch on your Nrf2 signaling pathway
An informative interview to start this year with the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease: The Antioxidant Dilemma with Dr. Christine Houghton “The thing about science is, the more you know, the more you realise you don’t know. And I have … Continue reading Switch on your Nrf2 signaling pathway
This 2020 review subject concerned a leading cause of blindness: “Advanced glycation end products (AGEs) are toxic compounds that have adverse effects on many tissues including the retina and lens. AGEs promote formation of reactive oxygen species (ROS), which, in turn, boost production of AGEs, a vicious cycle. Diabetic retinopathy (DR) is a devastating microvascular … Continue reading Eat broccoli sprouts for your eyes
Two 2020 reviews covered some aspects of a broccoli sprouts primary action – NRF2 signaling pathway activation: “Full understanding of the properties of drug candidates rely partly on the identification, validation, and use of biomarkers to optimize clinical applications. This review focuses on results from clinical trials with four agents known to target NRF2 signaling … Continue reading Eat broccoli sprouts to pivot your internal environment’s signals