Glutathione primes β-glucan-trained immunity

Two 2021 papers on glutathione interactions with β-glucan, with the first studying human cells from healthy donors: “(1→3)-β-D-Glucan stimulation induces epigenetic and transcriptomic changes in monocytes associated with increased glutathione (GSH) synthesis and metabolism. Intracellular glutathione levels were crucial in regulating several monocyte antifungal functions including resilience to oxidative stress, immunometabolism, nitric oxide production, phagocytosis, … Continue reading Glutathione primes β-glucan-trained immunity

Nrf2 and circadian rhythm

This 2021 rodent study investigated aging’s effects: “We investigated aging consequences on temporal patterns of antioxidant defenses, molecular clock machinery, and blood pressure. We observed circadian rhythms of catalase (CAT) and glutathione peroxidase (GPx) mRNA expression, as well as ultradian rhythms of Nrf2 mRNA levels, in the hearts of young adult rats. We also found … Continue reading Nrf2 and circadian rhythm

Eat broccoli sprouts for your liver

This 2021 rodent study investigated sulforaphane pretreatment’s role in reducing liver injuries: “As a double blood supply organ of the portal vein and artery, the liver is highly sensitive to ischemia, and is one of the common organs to suffer from hepatic ischemia-reperfusion injury (HI/RI). HI/RI leads to overproduction of reactive oxygen species (ROS). Overdoses … Continue reading Eat broccoli sprouts for your liver

Remembering encounters provides future benefits

Two 2021 papers on trained immunity, with the first a review: “Effective memory immune responses rely on interaction between innate and adaptive immune cells. While activation of innate immunity provides the first line of defense against infections, it also primes the adaptive immune response. Adaptive immunity can enhance antimicrobial machinery of innate cells, making them … Continue reading Remembering encounters provides future benefits

Natural products vs. neurodegenerative diseases

I was recently asked about taking rapamycin for its effects on mTOR. I replied that diet could do the same thing. Here’s a 2021 review outlining such effects: “As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available. Recent studies have revealed … Continue reading Natural products vs. neurodegenerative diseases

Eat broccoli sprouts every day

This 2020 rodent study demonstrated benefits from daily cooked broccoli intake, even when it contained no myrosinase enzyme and no sulforaphane: “Broccoli consumption by rats influenced several metabolic pathways that impact liver health. Plasma metabolite changes are potential biomarkers of liver health, and also monitor broccoli benefits. Rats fed a broccoli diet exhibited an enhanced … Continue reading Eat broccoli sprouts every day

Eat mushrooms for a longer life?

Two papers, starting with a 2021 meta-analysis of mushroom intake: “Mushroom consumption was associated with a lower risk of total mortality in this nationally representative sample of US adults. 15,546 participants were included, mean age 44.3 years. During a mean follow-up duration of 19.5 years, a total of 5,826 deaths were documented. Participants who reported … Continue reading Eat mushrooms for a longer life?

The amino acid ergothioneine

A trio of papers on ergothioneine starts with a 2019 human study. 3,236 people without cardiovascular disease and diabetes mellitus ages 57.4 ± 6.0 were measured for 112 metabolites, then followed-up after 20+ years: “We identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be … Continue reading The amino acid ergothioneine

Eat broccoli sprouts daily, and manage weight

This 2018 human study found: “The objective of this study was to determine whether daily broccoli consumption alters absorption and metabolism of isothiocyanates derived from broccoli glucosinolates. We conducted a randomised cross-over human study (n = 18) balanced for BMI and glutathione S-transferase μ 1 (GSTM1) genotype in which subjects consumed a control diet with … Continue reading Eat broccoli sprouts daily, and manage weight

Week 56 of Changing to a youthful phenotype with sprouts

1. Per Improving healthy compounds of broccoli sprouts and Broccoli sprouts’ immune effects, this week I added mustard sprouts and red cabbage sprouts to my twice-daily routine of eating 3-day-old microwaved broccoli sprouts. At first, I started mustard and red cabbage seeds with the same 10.7 gram weight (one tablespoon) of seeds. They grew well … Continue reading Week 56 of Changing to a youthful phenotype with sprouts

Broccoli sprouts’ immune effects

Two 2021 papers, with the first’s subject being sulforaphane’s immune effects: “Effects of sulforaphane (SFN) on immune response generate scientific interest because of its bioavailability, which is much higher than other phytochemicals, and its capacity to induce Nrf2 target genes. Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail. SFN … Continue reading Broccoli sprouts’ immune effects

Several diseases, one treatment?

This 2021 review summarized three dietary supplements’ effects on psychiatric symptoms: “Upregulation of Nrf2 has been suggested as a common therapeutic target for major neuropsychiatric disorders. In this paper, evidence is presented showing how NAC [N-acetyl-cysteine], coenzyme Q10 (CoQ), and melatonin can ameliorate many important effects of oxidative stress by upregulating Nrf2. Given its key … Continue reading Several diseases, one treatment?

Train your gut microbiota with taurine

This 2021 rodent study found: “We show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to expansion of taxa that utilize taurine. Supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Taurine … Continue reading Train your gut microbiota with taurine

Eat broccoli sprouts for your kidneys

Starting Year 7 of curating research with a 2021 review of kidney disease and sulforaphane: “Many chronic kidney disease (CKD) patients progress to end-stage kidney disease – the ultimate in failed prevention. While increased oxidative stress is a major molecular underpinning of CKD progression, no treatment modality specifically targeting oxidative stress has been established clinically. … Continue reading Eat broccoli sprouts for your kidneys

Harnessing endogenous defenses with broccoli sprouts

This 2019 article was by the author of Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. It isn’t widely available, so I’ll quote liberally: “Demand for solutions to digestive health issues is accelerating, especially since both scientific literature and popular press dedicate significant resources to … Continue reading Harnessing endogenous defenses with broccoli sprouts