This 2022 cell study investigated yeast cell wall β-glucan’s effects on angiogenesis:
“Angiogenesis, the formation of new blood vessels, is essential for embryonic development and physiological damage repair, such as wound healing and post-ischemic tissue restoration. It is also essential for pathological processes, such as diabetic retinopathy, rheumatoid arthritis, and atherosclerosis.
We evaluated physical and functional interactions of β-glucan with HDAC5, including the scratched wound, tube formation, and rat aortic ring assays. β-glucan-induced HDAC5 pathway mediates cell migration and formation of tubes and microvessels in vitro and ex vivo.
Our findings demonstrate that β-glucan-induced HDAC5 phosphorylation is important in endothelial cell angiogenesis. Further investigations into how β-glucan phosphorylates HDAC5 are required. There is also a need to identify a receptor that specifically binds to β-glucan in vascular endothelial cells.
β-glucan could be useful in developing new strategies in therapeutic angiogenesis for conditions such as cardiovascular disease and diabetes.”
https://www.sciencedirect.com/science/article/abs/pii/S0141813022010273 “Yeast beta-glucan mediates histone deacetylase 5-induced angiogenesis in vascular endothelial cells” (not freely available). Thanks to Dr. Chan-Gi Pack for providing a copy.